The first total synthesis of (±)-pallescensin B
نویسندگان
چکیده
Pallescensins are a group of furanosesquiterpenoids isolated from the marine sponge Disidea pallescens by Cimino et al.1 The common feature of these terpenoids is that they all contain a furan moiety; however they have carbon skeletons of varying complexity. Among the pallescensins, pallescensin B 1 presents the most complex architecture, with a unique bicyclo[4.2.2]decane system fused to a furan moiety. Interestingly, bicyclo[4.2.2]decane skeletons are relatively rare among natural products, the only other known example being nakafuran-8 2.2
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